Effects of Psidium guajava ethanolic leaf extract on epidermal wound healing in streptozotocin-induced diabetic male Wistar rats

Olushola E. Adeleye; James M. Enikuomehin; Eyitayo S. Ajibola; Oluwatodimu A. Adekoya; Adenike I. Adeleye; Cecilia O. Oguntoye

doi:10.5455/ajvs.67214

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Original Article
Online Published: 29 Jul 2022

AJVS. 2022; 75(1): 25-33

doi: 10.5455/ajvs.67214

Effects of Psidium guajava ethanolic leaf extract on epidermal wound healing in streptozotocin-induced diabetic male Wistar rats

Olushola E. Adeleye, James M. Enikuomehin, Eyitayo S. Ajibola, Oluwatodimu A. Adekoya, Adenike I. Adeleye, Cecilia O. Oguntoye.

Abstract
Diabetes mellitus (DM) occurrence is increasing. Canine DM is multifactorial and global prevalence is 0.005 to 1.5% affecting both sexes between 4-14 years old. Diabetic foot ulcer is a complication of DM impairing wound healing. Psidium guajava (PG) is a food and medicinal plant containing quercetin (a potent antioxidant) in its leaf and used in locally to manage DM. Effects of ethanolic extract of PG leaves on in vivo animal diabetic models have not been investigated indeptly with little documented information on the effect of PG extract on wound management in diabetics. This study evaluated the beneficial role of PG ethanolic leaf extract (PGELE) in an experimental model of diabetes-related wound healing disorders.
Ethanolic extracts were prepared from PG leaves. Thirty male Wistar rats (190-205 g) were separated into 6 groups (n = 5) and treated for 2 weeks. Group I (control), II (streptozotocin 60 mg/kg once), III & IV (streptozotocin 60 mg/kg once, PGELE (125 & 250 mg/kg rat/day) per os), V (streptozotocin 60 mg/kg once, glibenclamide 5 mg/kg b.w) and VI (PGELE 250 mg/kg orally). Plasma glucose was determined by glucometer. 10 x 10 mm wounds were made under anaesthesia. Full blood count was done by microscopy. Data were analysed using ANOVA at α0.05.
Glucose concentration was significantly higher in II (583 ± 4.16 mg/dL) compared to others. Wound contraction rates were significantly slower in II (41 ± 0.23 %) compared to others. There was no difference in haematology. PGELE improved wound healing in streptozotocin-induced diabetic Wistar rats.

Key words: diabetes, Psidium guajava, Quercetin, Wistar rats, wound

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Pubmed Style

Adeleye OE, Enikuomehin JM, Ajibola ES, Adekoya OA, Adeleye AI, Oguntoye CO. Effects of Psidium guajava ethanolic leaf extract on epidermal wound healing in streptozotocin-induced diabetic male Wistar rats. AJVS. 2022; 75(1): 25-33. doi:10.5455/ajvs.67214

Web Style

Adeleye OE, Enikuomehin JM, Ajibola ES, Adekoya OA, Adeleye AI, Oguntoye CO. Effects of Psidium guajava ethanolic leaf extract on epidermal wound healing in streptozotocin-induced diabetic male Wistar rats. https://www.alexjvs.com/?mno=67214 [Access: May 04, 2025]. doi:10.5455/ajvs.67214

AMA (American Medical Association) Style

Adeleye OE, Enikuomehin JM, Ajibola ES, Adekoya OA, Adeleye AI, Oguntoye CO. Effects of Psidium guajava ethanolic leaf extract on epidermal wound healing in streptozotocin-induced diabetic male Wistar rats. AJVS. 2022; 75(1): 25-33. doi:10.5455/ajvs.67214

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Harvard Style

Adeleye, O. E., Enikuomehin, . J. M., Ajibola, . E. S., Adekoya, . O. A., Adeleye, . A. I. & Oguntoye, . C. O. (2022) Effects of Psidium guajava ethanolic leaf extract on epidermal wound healing in streptozotocin-induced diabetic male Wistar rats. AJVS, 75 (1), 25-33. doi:10.5455/ajvs.67214

Turabian Style

Adeleye, Olushola E., James M. Enikuomehin, Eyitayo S. Ajibola, Oluwatodimu A. Adekoya, Adenike I. Adeleye, and Cecilia O. Oguntoye. 2022. Effects of Psidium guajava ethanolic leaf extract on epidermal wound healing in streptozotocin-induced diabetic male Wistar rats. Alexandria Journal of Veterinary Sciences, 75 (1), 25-33. doi:10.5455/ajvs.67214

Chicago Style

Adeleye, Olushola E., James M. Enikuomehin, Eyitayo S. Ajibola, Oluwatodimu A. Adekoya, Adenike I. Adeleye, and Cecilia O. Oguntoye. "Effects of Psidium guajava ethanolic leaf extract on epidermal wound healing in streptozotocin-induced diabetic male Wistar rats." Alexandria Journal of Veterinary Sciences 75 (2022), 25-33. doi:10.5455/ajvs.67214

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