The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine

Azza M. Mohamed; Mohamed H. Atwa; Diana M. Abulmagd

doi:10.5455/ajvs.221057

2025, Vol: 86

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Original Article
Online Published: 10 Nov 2024

AJVS. 2025; 84(0): 120-131

doi: 10.5455/ajvs.221057

The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine

Azza M. Mohamed, Mohamed H. Atwa, Diana M. Abulmagd.

Abstract
Spirulina's nutritional profile, non-toxicity, and medicinal properties make it a popular choice for use as a nutraceutical feed additive. This study investigates the impact of Spirulina platensis (SPL) algae addition in sheep ration on some of their haemato-biochemical parameters and the humeral immune response to the inactivated FMD vaccine. This experimental work was conducted using 15 sheep classified in 3 groups (5 sheep/ group). The first group was kept without ration additive or vaccination. The second group was vaccinated with FMD vaccine without ration additive while the third group received Spirulina platensis (SP) at the rate of 1gm / 10 kg BW /day starting from one week before vaccination and till the end of experiment (40 weeks). Evaluation of sheep immune response was investigated by measuring the total serum protein, albumin, globulin and the antibody titer by serum neutralization test (SNT) and indirect enzyme linked immune sorbent assay (ELISA). It was found that there was a marked increase in the levels of total protein, globulin and FMD antibody titer in the serum of sheep received SP than in vaccinated sheep without SP ration additive. Depending on these results we can conclude that Spirulina Platenesis has an immune modulatory effect in sheep vaccinated with FMD vaccine suggesting that it can increase the protection rate and immunity duration against the disease infection.

Key words: Spirulina platenesis, FMD, Inactivated vaccine, SNT, ELISA,

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Pubmed Style

Mohamed AM, Atwa MH, Abulmagd DM. The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine. AJVS. 2025; 84(0): 120-131. doi:10.5455/ajvs.221057

Web Style

Mohamed AM, Atwa MH, Abulmagd DM. The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine. https://www.alexjvs.com/?mno=221057 [Access: May 03, 2025]. doi:10.5455/ajvs.221057

AMA (American Medical Association) Style

Mohamed AM, Atwa MH, Abulmagd DM. The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine. AJVS. 2025; 84(0): 120-131. doi:10.5455/ajvs.221057

Vancouver/ICMJE Style

Mohamed AM, Atwa MH, Abulmagd DM. The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine. AJVS. (2025), [cited May 03, 2025]; 84(0): 120-131. doi:10.5455/ajvs.221057

Harvard Style

Mohamed, A. M., Atwa, . M. H. & Abulmagd, . D. M. (2025) The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine. AJVS, 84 (0), 120-131. doi:10.5455/ajvs.221057

Turabian Style

Mohamed, Azza M., Mohamed H. Atwa, and Diana M. Abulmagd. 2025. The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine. Alexandria Journal of Veterinary Sciences, 84 (0), 120-131. doi:10.5455/ajvs.221057

Chicago Style

Mohamed, Azza M., Mohamed H. Atwa, and Diana M. Abulmagd. "The effect of Spirulina Platenisis supplementation on the immune response to FMD in sheep vaccinated with inactivated FMD vaccine." Alexandria Journal of Veterinary Sciences 84 (2025), 120-131. doi:10.5455/ajvs.221057

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APA (American Psychological Association) Style

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