Abstract
Cardiovascular diseases, systemic inflammation and metabolic syndromes (METS) become great global concern. Obesity mostly related with all previously described complications include non-alcoholic fatty liver (NAFLD). Different models and studies were designated to resolve the clues of obesity and related disorders. These concerns raised the alarm against fatty food especially, when allocated with physical dormancy due to the modern lifestyle.
A good alternative to avoid complication-related obesity by reducing daily calorie intake which defined globally as calorie restriction (CR) and may represent an important therapeutic approach. The current study were designed to assess the consequence of CR on body weight as an indicator for obesity and how this can reflected on the general health status in the rat model.
Animals were divided into three groups, control (CD) received normal diet; high fat diet group (HFD) received 20% fat and calorie restriction diet (CRD) received 4% fat. Acquiesced data showed that CRD group had the lowermost body weight and the internal fat decreased nearly 40% compared to HFD group. It is noteworthy to mention calorie restriction did not affect satiety of different groups as the energy intake remains steady among all groups. Moreover, CR significantly improves the level of inflammatory cytokines, as well as biochemical and histological parameters. These improvements were clearly shown in the antihyperlipemic effect, reduction of hepatocytes ballooning and degeneration. Together, the present data suggest that CR can improve the general health quality, diminishes low grade inflammation and ameliorate NAFLD outcomes.

Key words: High fat diet, Calorie restriction, CRP, cytokines, NAFLD