E-ISSN 2536-9520 | ISSN 1110-2047
 
2026, Vol: 88
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Original Article
Online Published: 03 Nov 2025
 


The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies

Abeer E. Elsayed, Abdeldayem Zakaria, Abdel Hasseb A. Fayed, Eman Khalifa, Norhan E. Khalifa, Hebatallah M. Saad.


Abstract
Abstract
Background: Type 2 diabetes mellitus (T2DM) is a pandemic public health metabolic disease with organ-related complications.
Aims: The present study aimed to investigate the comparative potential therapeutic efficacy of curcumin nanoparticles (Cur-NPs) and chromium chloride nanoparticles (CrCl-NP) in alleviating pancreatic and hepatic damage in streptozotocin (STZ)-induced T2DM in a male Wistar rat model.
Methods: Seventy male rats were randomly allocated into seven experimental groups: Control, T2DM, Cur-NPs treated-T2DM group, curcumin (Cur) treated-T2DM group, CrCl-NPs treated-T2DM group, chromium chloride (CrCl) treated-T2DM group, and Metformin treated-T2DM group. All the treatments were administered orally once daily for sixty consecutive days.
Results: T2DM group exhibits a significant increase in glycemia, serum fructosamine and lipid profile, liver function, and malondialdehyde (MDA), along with a decrease in serum antioxidant enzyme activities, such as glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT). Moreover, the histopathological and immunohistochemical analyses showed marked pancreatic and hepatic tissue damage in the T2DM group, including shrunken pancreatic islets, mononuclear infiltration, hepatic congestion, ductular hyperplasia, and fatty degeneration, as well as increased glucagon and decreased insulin expression. However, the treatment with Cur-NPs, Cur, CrCl-NPs, CrCl and Metformin significantly improved these biochemical and histological alterations, with Cur-NPs and Metformin showing the most pronounced protective and restorative effect against diabetes complications.
Conclusion: Cur-NPs and Metformin were the most effective interventions to create protection against hepatic and pancreatic complications in diabetic rats.

Key words: Curcumin-nanoparticles, Chromium chloride-nanoparticles, Streptozotocin, antioxidants, Liver function, Immunohistochemistry, Histopathology, rats, pandemic and public health.


 
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How to Cite this Article
Pubmed Style

Elsayed AE, Zakaria A, Fayed AHA, Khalifa E, Khalifa NE, Saad HM. The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies. AJVS. 2026; 88(0): 13-28. doi:10.5455/ajvs.288569

Web Style

Elsayed AE, Zakaria A, Fayed AHA, Khalifa E, Khalifa NE, Saad HM. The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies. https://www.alexjvs.com/?mno=288569 [Access: February 04, 2026]. doi:10.5455/ajvs.288569

AMA (American Medical Association) Style

Elsayed AE, Zakaria A, Fayed AHA, Khalifa E, Khalifa NE, Saad HM. The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies. AJVS. 2026; 88(0): 13-28. doi:10.5455/ajvs.288569


Vancouver/ICMJE Style

Elsayed AE, Zakaria A, Fayed AHA, Khalifa E, Khalifa NE, Saad HM. The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies. AJVS. (2026), [cited February 04, 2026]; 88(0): 13-28. doi:10.5455/ajvs.288569


Harvard Style

Elsayed, A. E., Zakaria, . A., Fayed, . A. H. A., Khalifa, . E., Khalifa, . N. E. & Saad, . H. M. (2026) The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies. AJVS, 88 (0), 13-28. doi:10.5455/ajvs.288569


Turabian Style

Elsayed, Abeer E., Abdeldayem Zakaria, Abdel Hasseb A. Fayed, Eman Khalifa, Norhan E. Khalifa, and Hebatallah M. Saad. 2026. The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies. Alexandria Journal of Veterinary Sciences, 88 (0), 13-28. doi:10.5455/ajvs.288569


Chicago Style

Elsayed, Abeer E., Abdeldayem Zakaria, Abdel Hasseb A. Fayed, Eman Khalifa, Norhan E. Khalifa, and Hebatallah M. Saad. "The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies." Alexandria Journal of Veterinary Sciences 88 (2026), 13-28. doi:10.5455/ajvs.288569


MLA (The Modern Language Association) Style

Elsayed, Abeer E., Abdeldayem Zakaria, Abdel Hasseb A. Fayed, Eman Khalifa, Norhan E. Khalifa, and Hebatallah M. Saad. "The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies." Alexandria Journal of Veterinary Sciences 88.0 (2026), 13-28. Print. doi:10.5455/ajvs.288569


APA (American Psychological Association) Style

Elsayed, A. E., Zakaria, . A., Fayed, . A. H. A., Khalifa, . E., Khalifa, . N. E. & Saad, . H. M. (2026) The Possible Ameliorating Effects of Nano Curcumin or Nano Chromium Against STZ-Induced T2DM in Rat model: Biochemical, Histopathological and Immunohistochemical Studies. Alexandria Journal of Veterinary Sciences, 88 (0), 13-28. doi:10.5455/ajvs.288569




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    Egypt.

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