Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats

Ibrahim A. Mahamat; El Sayed E. Mehanna; Samah S. Oda; Asmaa F. Khafaga; Dina R.S. Gad El-Karim

doi:10.5455/ajvs.90234

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Original Article
Online Published: 23 Aug 2021

AJVS. 2021; 70(2): 76-85

doi: 10.5455/ajvs.90234

Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats

Ibrahim A. Mahamat, El Sayed E. Mehanna, Samah S. Oda, Asmaa F. Khafaga, Dina R.s. Gad El-karim.

Abstract
Lead is one of the toxic heavy metals which were proved to induce several deleterious changes in different body organs especially central nervous system, liver and kidney. Rhoidiola species are medicinal plants which were used in treatment of several diseases for many years all over the world. This study was designed to detect the hematological, biochemical and pathological changes in relation to lead-induced hepat-renal toxicity, besides the possible ameliorative role of Rhodiola rosea extract against this toxicity in rats. Oral exposure of rats to lead acetate (25mg/Kg) for eight weeks resulted in a significant increase in liver-related enzymes (AST, ALT and ALP), different types of bilirubin, disturbance in serum proteinogram, besides a significant elevation in serum urea and creatinine level, without any significant changes in hemograme. Lead-induced oxidative stress in both of hepatic and renal tissues was indicated by depletion of their glutathione (GSH) content, decreased catalase enzyme (CAT) activity and elevated content of malondialdehyde (MDA). The previous changes were confirmed histopathologically by presence of several necrotic and degenerative lesions in hepatic and renal tissues. Contrariwise, the above mentioned changes were partially ameliorated upon co-administration of Rhodiola rosea extract (200 and 400 mg/Kg), but, high dose of Rhodiola extract mostly mitigated these changes than 200 mg/Kg dose. In conclusion, Rhodiola extract can ameliorate lead-induced hepato-nephrotoxicity and its related biochemical and pathological changes.

Key words: Lead;Rats;rhodiola;hepato-renal Toxicity

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How to Cite this Article

Pubmed Style

Mahamat IA, Mehanna ESE, Oda SS, Khafaga AF, El-karim DRG. Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats. AJVS. 2021; 70(2): 76-85. doi:10.5455/ajvs.90234

Web Style

Mahamat IA, Mehanna ESE, Oda SS, Khafaga AF, El-karim DRG. Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats. https://www.alexjvs.com/?mno=90234 [Access: May 04, 2025]. doi:10.5455/ajvs.90234

AMA (American Medical Association) Style

Mahamat IA, Mehanna ESE, Oda SS, Khafaga AF, El-karim DRG. Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats. AJVS. 2021; 70(2): 76-85. doi:10.5455/ajvs.90234

Vancouver/ICMJE Style

Mahamat IA, Mehanna ESE, Oda SS, Khafaga AF, El-karim DRG. Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats. AJVS. (2021), [cited May 04, 2025]; 70(2): 76-85. doi:10.5455/ajvs.90234

Harvard Style

Mahamat, I. A., Mehanna, . E. S. E., Oda, . S. S., Khafaga, . A. F. & El-karim, . D. R. G. (2021) Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats. AJVS, 70 (2), 76-85. doi:10.5455/ajvs.90234

Turabian Style

Mahamat, Ibrahim A., El Sayed E. Mehanna, Samah S. Oda, Asmaa F. Khafaga, and Dina R.s. Gad El-karim. 2021. Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats. Alexandria Journal of Veterinary Sciences, 70 (2), 76-85. doi:10.5455/ajvs.90234

Chicago Style

Mahamat, Ibrahim A., El Sayed E. Mehanna, Samah S. Oda, Asmaa F. Khafaga, and Dina R.s. Gad El-karim. "Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats." Alexandria Journal of Veterinary Sciences 70 (2021), 76-85. doi:10.5455/ajvs.90234

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