E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats

Elsayed mehanna, ibrahim mahamat, Samah oda, Asmaa khafaga, Dina Gad elkarim.

Abstract
Lead is one of the toxic heavy metals which were proved to induce several deleterious changes in different body organs especially central nervous system, liver and kidney. Rhoidiola species are medicinal plants which were used in treatment of several diseases for many years all over the world. This study was designed to detect the hematological, biochemical and pathological changes in relation to lead-induced hepat-renal toxicity, besides the possible ameliorative role of Rhodiola rosea extract against this toxicity in rats. Oral exposure of rats to lead acetate (25mg/Kg) for eight weeks resulted in a significant increase in liver-related enzymes (AST, ALT and ALP), different types of bilirubin, disturbance in serum proteinogram, besides a significant elevation in serum urea and creatinine level, without any significant changes in hemograme. Lead-induced oxidative stress in both of hepatic and renal tissues was indicated by depletion of their glutathione (GSH) content, decreased catalase enzyme (CAT) activity and elevated content of malondialdehyde (MDA). The previous changes were confirmed histopathologically by presence of several necrotic and degenerative lesions in hepatic and renal tissues. Contrariwise, the above mentioned changes were partially ameliorated upon co-administration of Rhodiola rosea extract (200 and 400 mg/Kg), but, high dose of Rhodiola extract mostly mitigated these changes than 200 mg/Kg dose. In conclusion, Rhodiola extract can ameliorate lead-induced hepato-nephrotoxicity and its related biochemical and pathological changes.

Key words: Lead;Rats;rhodiola;hepato-renal Toxicity


 
ARTICLE TOOLS
Abstract
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Elsayed mehanna
Articles by ibrahim mahamat
Articles by Samah oda
Articles by Asmaa khafaga
Articles by Dina Gad elkarim
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

mehanna E, mahamat i, oda S, khafaga A, elkarim DG, . Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats.


Web Style

mehanna E, mahamat i, oda S, khafaga A, elkarim DG, . Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats. http://www.alexjvs.com/?mno=90234 [Access: August 23, 2021].


AMA (American Medical Association) Style

mehanna E, mahamat i, oda S, khafaga A, elkarim DG, . Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats.



Vancouver/ICMJE Style

mehanna E, mahamat i, oda S, khafaga A, elkarim DG, . Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats.



Harvard Style

mehanna, E., mahamat, i., oda, S., khafaga, A., elkarim, D. G. & (0) Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats.



Turabian Style

mehanna, Elsayed, ibrahim mahamat, Samah oda, Asmaa khafaga, Dina Gad elkarim, and . 0. Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats.



Chicago Style

mehanna, Elsayed, ibrahim mahamat, Samah oda, Asmaa khafaga, Dina Gad elkarim, and . "Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats."



MLA (The Modern Language Association) Style

mehanna, Elsayed, ibrahim mahamat, Samah oda, Asmaa khafaga, Dina Gad elkarim, and . "Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats."



APA (American Psychological Association) Style

mehanna, E., mahamat, i., oda, S., khafaga, A., elkarim, D. G. & (0) Lead-induced Hepato-renal Toxicosis and the Ameliorative Role of Rhodiola Rosea Extract in Albino Rats.





Most Viewed Articles
  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract & References

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract & References » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Most Downloaded
  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract & References » doi: 10.5455/ajvs.47290

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Most Cited Articles
  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333
    Cited : 10 times [Click to see citing articles]

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232
    Cited : 8 times [Click to see citing articles]

  • Effect of Dietary Replacement of Inorganic Zinc by Organic or Nanoparticles Sources on Growth Performance, Immune Response and Intestinal Histopathology of Broiler Chicken
    Mohamed El-Katcha, Mosad A. Soltan, M. El-badry
    AJVS. 2017; 55(2): 129-145
    » Abstract » doi: 10.5455/ajvs.266925
    Cited : 7 times [Click to see citing articles]

  • Molecular Characterization, Antimicrobial Susceptibility and Salt Tolerance of Aeromonas hydrophila from Fresh, Brackish and Marine fishes
    Basma Dahdouh, Ola Basha, Samy Khalil, Mahmoud Tanekhy
    AJVS. 2016; 48(2): 46-53
    » Abstract & References » doi: 10.5455/ajvs.208107
    Cited : 6 times [Click to see citing articles]

  • The Growth Promoting Effect of Beta-glucan in Comparison with Sodium Butyrate in Broiler Chicks
    Abd El-Salam F. El-Sawy, Zeynab Kh. El-Maddawy, Hawary S. Ibrahiem and El-Sadeq Bo-Ghazel
    AJVS. 2015; 44(1): 23-37
    » Abstract & References » doi: 10.5455/ajvs.163992
    Cited : 5 times [Click to see citing articles]